Endocrine Abstracts

A number of growth factors and their receptor signalling pathways are expressed in the embryonic and adult pancreas. Recent evidence from studies using murine gene-targeting strategies has implicated insulin and IGF-1 receptor and post-receptor signalling pathways in beta cell function. A number of roles for these signalling mechanisms have been reported in both beta cell development and survival and in regulating insulin gene expression and insulin secretion. Global and condi...